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Calretinin antibody, a calcium binding protein related to calmodulin and calbindin-D28k, is present in subsets of neurons throughout the brain and spinal cord, including sensory ganglia. Studies have shown that calretinin, like calbindin, may be neuroprotective. Immunohistochemical studies have shown calretinin may be useful in distinguishing mesotheliomas from lung adenocarcinomas, marking approximately 80-90% of all mesotheliomas. When used in combination with E-cadherin, calretinin may be a suitable panel for distinguishing metastatic carcinomas and mesotheliomas in pleural lesions.
Nuclear and cytoplasmic
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