D2-40 antibody is a selective marker of lymphatic endothelium in normal tissues and vascular lesions. Studies have shown [D2-40] staining in lymphatic channel endothelium, but not in the adjacent capillary. In the same study, D2-40 stained endothelium of lymphangiomas; whereas hemangiomas, glomus tumors, angiolipomas, pyogenic granulomas and vascular malformations were negative for staining. D2-40 has also been shown to react with Kaposi’s sarcoma and a subset of angiosarcomas. Studies indicate that D2-40 may be a very specific marker for malignant mesothelioma.