BOB-1

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BOB-1 antibody is a B-lymphocyte-specific transcriptional co-activator for Oct-1 and Oct-2 transcription factors. BOB-1 and Oct-2 are useful for the B-lineage determination of CD20-plasmablastic or primary effusion subtypes of diffuse large B-cell lymphoma (DLBCL). Other studies have shown BOB-1, CD79a and Cyclin E are useful markers for discriminating classical Hodgkin’s lymphoma from primary mediastinal large B-cell lymphoma. The strong nuclear expression of BOB-1 and Oct-2 by germinal center derived lymphomas makes these antibodies a novel class of broad spectrum B-lineage IHC markers to aid in the differential diagnosis of lymphomas.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

TG14

Isotype

IgG1

Antigen

Prokaryotic recombinant protein containing 116 amino acids of the C-terminus of BOB-1

Localization

Nuclear

Positive Control

Tonsil

1. Hoeller S, et al. Histopathology. 2010 Jan; 56(2):217-28.
2. Advani AS, et al. Leuk Lymphoma. 2010 Apr; 51(4):606-12.
3. McCune RC, Syrbu SI, Vasef MA. Mod Pathol. 2006 Jul; 19(7):1010-8.
4. Chu PG, et al. Am J Clin Pathol. 2006 Oct; 126(4):534-44.
5. Browne P, et al. Am J Clin Pathol. 2003 Nov; 120(5):767-77.

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