SMAD4 [EP618Y] is a rabbit monoclonal antibody that is intended for laboratory use in the qualitative identification of SMAD4 protein by immunohistochemistry (IHC) in formalin-fixed paraffin-embedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist.
SMAD4 is a DNA-binding protein that belongs to the SMAD family of transcription factors. Activated SMAD4 complexes accumulate in the nucleus and act as mediators of TGF-β signal transduction (1,2). SMAD4 mutations or deletions are linked to hereditary hemorrhagic telangiectasia syndrome, and juvenile polyposis syndrome (1). SMAD4 mutations or deletions have also been implicated in multiple cancer indications including cholangiocarcinoma, colorectal, head and neck, and pancreatic cancer (2,3).