PAX8 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. PAX8 is involved in kidney cell differentiation, thyroid development, or thyroid dysgenesis.
PAX8 is expressed in a high percentage of renal cell carcinomas and ovarian cancers. This mouse monoclonal PAX8 antibody [BC12] has been designed to target a restricted epitope and exhibits higher specificity and provides sharper staining than the PAX8 rabbit polyclonal antibody. Unlike the polyclonal PAX8, this mouse monoclonal antibody does not stain B-cells and does not recognize epitopes of pancreatic origin and neuroendocrine cells in stomach and colon; thus, providing superior specificity. The expression of the mouse monoclonal PAX8 target antigens was found in normal kidney, thyroid, and cervix, but was not identified in normal ovary. By Western blot, [BC12] has been shown to recognize PAX8 and not PAX2, PAX5 or PAX6 proteins.
PAX8 stains nuclei exclusively and performs well in formalin-fixed paraffin-embedded tissues. U.S. Patents 8,852,592, 9,417,243, and patents pending.