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p63 + P504S (PIN)
P504S is an enzyme in the ß-oxidation of branched-chain fatty acids. Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. p63, a homolog of the tumor suppressor p53, encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives. Expression of p63 is detected in prostate basal epithelial nuclei in normal prostate; however, is negative in malignant tumors of the prostate gland. p63 + P504S antibody may be an extremely useful aid in diagnosing prostatic intraepithelial neoplasia (PIN), especially in difficult and limited tissues cases.
| Intended Use | RUO |
|---|---|
| Species Reactivity | Human |
| Source | Mouse Monoclonal, Rabbit Polyclonal |
| Clone | 4A4 N/A |
| Isotype | IgG, IgG2a/kappa |
| Antigen | p63 P504S |
| Localization | Nuclear Granular Cytoplasm |
| Positive Control | Normal prostate and prostate adenocarcinoma |
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2. Signoretti S, et. al. p63 Is a Prostate Basal Cell Marker and Is Required for Prostate Development. Am J Pathol. 2000;157:1769-75.
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5. Rubin MA, et. al. α-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer. JAMA. 2002; 287:1662-70.
6. Luo J, et. al. Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer. Cancer Res. 2002; 62:2220-6.
7. Zhou M, et. al. Alpha-Methylacyl-CoA Racemase A Novel Tumor Marker Overexpressed in Several Human Cancers and Their Precursor Lesions. Am J Surg Pathol. 2002; 26:926-31.
8. Wu CL, et. al. Analysis of α-Methylacyl-CoA Racemase (P504S) Expression in High-Grade Prostatic Intraepithelial Neoplasia. Hum Pathol. 2004; 35:1008-13.
9. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
10. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.
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