Mammaglobin

Product Description

The mammaglobin gene was first identified using a differential screening approach directed at the isolation of novel, human breast cancer associated genes. Mammaglobin encodes a 10 kDa glycoprotein and is distantly related to a family of epithelial secretory proteins that includes rat estramustinebinding protein/prostatein and human Clara cell 10 kDa protein (CC10)/uteroglobin.¹⁵

Mammaglobin, a mammary-specific member of the uteroglobin family, is known to be overexpressed in human breast cancer. Studies suggest that mammaglobin is one of the first relatively mammary-specific and mammary sensitive markers (85%).¹⁵

Mammaglobin may be valuable used in a panel with GCDFP-15 and ER in evaluating tumors of unknown primary sites.

Specifications

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Han JH, Kang Y, Shin HC, Kim HS, Kang YM, Kim YB, Oh SY. Mammaglobin
expression in lymph nodes is an important marker of metastatic breast carcinoma.
(Polyclonal) Arch Pathol Lab Med. 2003 Oct;127(10):1330-4.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22,
Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove
Azide Salts.”
3. National Committee for Clinical Laboratory Standards (NCCLS). Protection of
laboratory workers from infectious diseases transmitted by blood and tissue; proposed
guideline. Villanova, PA 1991;7(9). Order code M29-P.