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Mammaglobin antibody encodes a 10 kDa glycoprotein and is distantly related to a family of epithelial secretory proteins that includes rat estramustine-binding protein, prostatein and human Clara cell 10 kDa proteins (CC10)/uteroglobin. Mammaglobin, a mammary-specific member of the uteroglobin family, has been shown to be overexpressed in human breast cancer. Studies suggest that mammaglobin is a relatively mammary-specific and mammary-sensitive marker. Mammaglobin may be valuable in a panel with GCDFP-15 and estrogen receptor in evaluating tumors of unknown primary sites.
Human, Mouse, Rat
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1. Han JH, Kang Y, Shin HC, Kim HS, Kang YM, Kim YB, Oh SY. Mammaglobin
expression in lymph nodes is an important marker of metastatic breast carcinoma.
(Polyclonal) Arch Pathol Lab Med. 2003 Oct;127(10):1330-4.
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Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove
3. National Committee for Clinical Laboratory Standards (NCCLS). Protection of
laboratory workers from infectious diseases transmitted by blood and tissue; proposed
guideline. Villanova, PA 1991;7(9). Order code M29-P.