L26 + CD3 antibodies allow B-cell and T-cell lymphomas to be identified on the same slide. L26 (CD20) reacts with the majority of B-cells present in peripheral blood and lymphoid tissues. In normal lymphoid tissue, L26 marks B-cells in germinal centers, particularly immunoblasts and rarely marks T-cells. This antibody has been shown to be a reliable pan B-cell marker. The rabbit monoclonal CD3 reacts with the intracytoplasmic portion of the CD3 antigen expressed by T-cells. CD3 stains human T-cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues.
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