Glutamine Synthetase

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Glutamine Synthetase antibody (GS) catalyzes the synthesis of glutamine, the major energy source of tumor cells. Accumulation of GS was first found in hepatocellular carcinoma (HCC). Liver biopsy for HCC detection is largely restricted to small hepatocellular lesions, which are often morphologically challenging, requiring careful distinction between dysplastic nodules (high-grade) and well-differentiated HCC. When a panel of GS, Heat Shock Protein 70 and Glypican 3 is used, if any 2 of the 3 are positive, the sensitivity and specificity for the detection of early HCC-G1 were 72% and 100% respectively.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

6/Glutamine Synthetase

Isotype

IgG2a

Antigen

Glutamine Synthetase

Localization

Cytoplasmic

Positive Control

Hepatocellular cancer

1. Zhuang Z, et al. Proteomic identification of glutamine synthetase as a differential marker for oligodendrogliomas and astrocytomas. J Neurosurg. 2011 Jun 17. [Epub ahead of print] 2. Long J, et al. Glutamine synthetase as an early marker for hepatocellular carcinoma based on proteomic analysis of resected small hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2010 Jun; 9(3):296-305.
3. Roskams T, Kojiro M. Pathology of early hepatocellular carcinoma: conventional and molecular diagnosis. Semin Liver Dis. 2010 Feb; 30(1):17-25. Epub 2010 Feb 19.
4. Sakamoto M. Early HCC: diagnosis and molecular markers. J Gastroenterol. 2009; 44 Suppl 19:108-11.
5. Di Tommaso L, et al. The application of markers (HAP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma. J Hepatol. 2009 Apr; 50 (4):746-54.
6. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
7. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005

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