This antibody reacts with human Glial Fibrillary Acidic Protein antibody and does not react with other intermediate filaments. Anti-GFAP stains astrocytes, ependymal cells and corresponding tumors. In the peripheral nervous system, GFAP stains Schwann cells, enteric glial cells and satellite cells. Weak staining of axons has been observed which is caused by cross-reaction with neurofilament. Studies have shown GFAP may be useful for distinguishing neoplasms of astrocytic origin from other neoplasms in the central nervous system. Negative staining has been observed with lymphatic tissue, muscle, gastrointestinal tract, liver, kidney, pancreas and bladder.