The estrogen receptor antibody (ER) is a 66 kDa protein that acts as an estrogen-dependent, nuclear hormone receptor. Studies have shown ER is present in the nuclei of epithelial cells in normal breast and endometrial tissues, as well as a subset of breast carcinomas. The ER protein has six functionally discrete domains; labeled A through F. ER [1D5] reacts with the amino-terminal domain in the A/B region of ER-alpha. This clone has been established to work in formalin-fixed, paraffin-embedded tissues and has been published in numerous breast cancer research studies.
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1. Paech K, et al. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 97. Sept 5; 277(5331):1508-1510.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
3. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991; 7(9). Order code M29-P.