Chromogranin A

Product Description

This antibody recognizes a protein of 68-75 kDa, identified as Chromogranin A (a protein of 439-amino acid which is encoded on chromosome 14). Although the epitopes for [LK2H10] and [PHE5] are not precisely mapped, experimental data suggests that they are different. A cocktail of LK2H10 and PHE5 is specifically designed for sensitive detection of Chromogranin A in formalin-fixed, paraffin-embedded tissues. Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas and other neuroendocrine tumors. Coexpression of Chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.^15-20

Specifications

1. Kamiya N, et al. Int J Urol. 2008 May; 15(5):423-8.
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3. Park SJ, et al. Appl Immunohistochem Mol Morphol. 2010 Jul; 18(4):348-52.
4. Conlon JM. Regul Pept. 2010 Nov; 165(1):5-11.