Synaptophysin antibody [clone 27G12] is a reliable marker for neuroendocrine and neuronal neoplasms, as well as their normal counterparts. Synaptophysin has a higher degree of specificity than NSE, but is often used in conjunction with CD56, NSE and Chromogranin. This new clone is very specific and provides sharper staining when compared to other rabbit synaptophysin antibodies. In-house studies, reference laboratories, European institutions and NordiQC have validated this antibody as a first line screener for neuroendocrine tumors.
1. Chejfec G, Falkmer S, Grimelius L, Jacobsson B, Rodensjo M, Wiedenmann B, Franke WW, Lee I, Gould VE. Synaptophysin. A new marker for pancreatic neuroendocrine tumors. Am J Surg Pathol 1987 Apr;11(4):241-247.
2. Wiedenmann B, Franke WW, Kuhn C, Moll R, Gould VE. Synaptophysin: a marker protein for neuroendocrine cells and neoplasms. Proc Natl Acad Sci U S A 1986 May;83(10):3500-3504.
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.