CDX2 is a homeobox gene that encodes an intestine-specific transcription factor and is expressed in the nuclei of epithelial cells of the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas (1,2). It has also been identified in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary (3). Studies have shown that the CDX2 marker is a more specific and sensitive marker when compared to CK20 (4). According to in-house studies, CDX2 [BC39] showed equal or superior sensitivity to clone CDX2-88, with virtually identical specificity.