Monoclonal antibody to human CD3, when used in conjunction with other antibodies, is regarded as a reliable pan T-cell antibody for the immunophenotyping of lymphomas in paraffin sections. Most T-cell lymphomas show positivity for CD3 with exception of the more aggressive large T-cell lymphomas and anaplastic large cell (CD30) lymphomas. CD3 immunoreactivity has also been reported in a minority of Reed-Sternberg cells of Hodgkin’s disease and in some histiocytic tumors. Studies suggest that CD3 with UCHL-1 identified the majority of T-cell lymphomas in paraffin sections.
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