CD19

Product Description

The Biocare CD19 antibody detects CD19, a 95 kDa cell surface glycoprotein expressed by cells of the B-cell lineage and follicular dendritic cells. CD19 functions as a coreceptor with CD21 and plays a critical role in B-cell signal transduction, regulating development, activation, and differentiation.^15,16 CD19 is expressed in pre-B cells and B cells and is considered a pan–B-cell antigen. It is among the first B-cell antigens expressed after HLA-DR and is also present in follicular dendritic cells. CD19 is absent in plasma cells, most T-cell lymphomas, and lymphocyte-predominant Hodgkin’s disease. While CD19 is expressed in various lymphomas and leukemias, expression may be weak or negative in follicular lymphoma and diffuse large B-cell lymphoma.^15,17,18

Specifications

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Masir N, et al. Histopathology. 2006 Feb; 48(3):239-46.
2. Ferkolj I, Ihan A, Markovic S. Hepatogastroenterology. 2005 Jul-Aug; 52(64):1128-33.
3. Ginaldi L, et al. J Clin Pathol. 1998 May; 51(5):364-9.