IHC Applications: Paget’s Disease of the Breast

Mammary Paget’s Disease (MPD) is a rare and often misdiagnosed type of breast cancer that primarily affects the nipple and areola complex.^2,7 It occurs in approximately 1- 4% of all breast cancer cases and typically presents with eczema-like changes, such as redness, itching, and scaling of the nipple and areola.^2,7 Most patients with MPD have one or more tumors inside the same breast, either breast carcinoma in situ or invasive breast carcinoma.^2,4,7 While IHC may not be the sole diagnostic tool for MPD, it may play a crucial role in confirming the disease and guiding treatment decisions.

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