Biocare Medical Launches 7 Novel IVD Antibodies for Clinical Diagnostic and Cancer Research Applications with a Focus on Immuno-Oncology

February 13, 2020 – Biocare Medical, a leading provider of innovative, automated immunohistochemistry (IHC) reagents and instrumentation, announces the launch of seven novel IVD IHC antibody markers for clinical diagnostics and research applications.The most recent launch focuses on several immuno-oncology markers, critical in aiding early-stage cancer drug developments and patient treatment.

Biocare re-developed a major antibody marker (S100 Protein), which is expressed in Schwannomas, ependymomas, astrogliomas, and nearly all melanomas (benign and malignant) and their metastases.Biocare’s new marker, S100 [4C4.9], lends a stronger and more robust staining signal for IHC applications vs. previous offerings.

Biocare also releases one mouse monoclonal and five novel rabbit monoclonal antibodies in the immuno-oncology space. Recombinant rabbit monoclonal antibodies are ideal for research applications for use with Multiplex IHC technologies and are not reliant upon hybridomas that may expire. CTLA-4 [CAL49], GITR [CAL8], LAG3 [CAL26], PD-1 [CAL20], CD22 (M) [BLCAM/1796], and E-Cadherin [CDH1/2208R] are now commercially available.

CTLA-4 – Ipilimumab, the first immunotherapeutic drug directed toward CTLA-4 inhibition, has demonstrated overall survival benefit in metastatic melanoma. Another CTLA-4 inhibitor, tremelimumab (IgG2 isotype), has also proven successful in metastatic melanoma and other malignancies1,2.

GITR – GITR modulation in preclinical models has shown promising antitumor activity via significant increase in effector T cells and decrease in Tregs3. Several human monoclonal antibodies that agonize GITR are currently undergoing phase I clinical studies in various solid malignancies. Preliminary results demonstrate an acceptable safety profile without dose limiting toxicities4-5.

LAG3 – Recent studies in a metastatic ovarian cancer mouse model showed that LAG-3 blockade leads to upregulation of other immune checkpoints (PD-1, CTLA4, and TIM-3), and combination therapy targeting LAG-3, PD-1, and CTLA-4 increases functional cytotoxic T cell levels while reducing Tregs and myeloid-derived suppressor cells6,7.

PD-1 – Treatments targeting PD-1 and its ligand, PD-L1, have also shown encouraging results in melanoma, non-small-cell lung cancer, and renal cell carcinoma8-10. This antibody can also be used in multiplex stains with other antibodies such as CD4, CD8, FOXP3, cytokeratin, and melanoma markers11.

CD22 (M) – May be a useful marker for phenotyping mature leukemias, as CD22 membrane expression has been shown to be limited to the late differentiation stages between mature B cells (CD22+) and plasma cells (CD22-)12, 13. CD22 is also strongly expressed in hairy cell leukemia14.

E-cadherin – A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate, and esophageal cancer.

“We are proud to be able to launch novel, IVD IHC markers that meet the highest standards in cancer diagnostics. This commitment to quality ensures Biocare is providing the best diagnostic and research utility possible,” said Dr. Jason Ramos, Vice President – Reagent Research and Development at Biocare Medical.

The new product launches continue Biocare Medical’s long-standing history of providing novel, high-quality reagents to customers looking to advance their research and diagnostic efficiency in the laboratory.

About Biocare Medical
Biocare Medical is a global leader in solutions for cancer research and diagnostics, providing: world-class reagents, including tissue-conserving simultaneous Multiplex antibody cocktails and detections; renowned Customer Care; and a comprehensive suite of advanced instrumentation for IHC, molecular, and histology testing. Customers include clinical anatomic pathology laboratories, pharmaceutical companies, CROs, and biotechnology companies as well as academic, government, military, and other non-profit laboratories. Biocare’s reagent portfolio includes primary antibodies, Multiplex IHC, and FISH probes for target indications. Biocare also offers a unique line of polymer detections for clinical, human, and animal research that deliver high sensitivity and exceptionally low background. The Company’s advanced platforms, intelliPATH™ and VALENT™, have been designed to meet every need from high throughput clinical diagnostics to flexible research requirements.

Press Contact:
John Steel
Director of Marketing and Ecommerce
Biocare Medical
jsteel@biocare.net

1. Buchbinder EI, McDermott DF. Cytotoxic T-lymphocyte antigen-4 blockade in melanoma. Clinical Therapeutics. 2015; 37:755-63. 2. Baecher-Allan C, et al. Human CD4+CD25+ regulatory T cells. Semin Immunol. 2004 Apr; 16(2):89-98. 3. Dempke WCM, et al. Second- and third-generation drugs for immunooncology treatment-The more the better? Eur J Cancer. 2017; 74:55– 72.  4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”  5. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.  6. Huang RY, et al. LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model. Oncotarget. 2015; 6:27359-77.  7. Huang RY, et al. Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer. Oncoimmunology. 2017; 6:e1249561.  8. Tumeh PC, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 2014 Nov 27; 515(7528):568-71.  9. D’Incecco A, et al. PD-1 and PD-L1 expression in molecularly selected non-small cell lung cancer patients. Br J Cancer. 2015 Jan 6; 112(1):95-102.  10. Tykodi SS. PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence. Onco Targets Ther. 2014 Jul 25; 7:1349-59.  11. Yang G, et al. A multiplex IHC evaluation of multiple immune checkpoint receptors and mismatch repair proteins in colorectal carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1026.  12. Perfetti V, et al. Membrane CD22 defines circulating myeloma-related cells as mature or later B cells. Lab Invest. 1997 Oct;77(4):333-44.  13. Batata A, Shen B. Immunophenotyping of subtypes of B-chronic (mature) lymphoid leukemia. A study of 242 cases. Cancer. 1992 Nov 15;70(10):2436-43.  14. Voigt JJ, et al. Immunochemical diagnosis of hepatic localizations in malignant lymphoid hematologic disease. Study of 80 cases. Gastroenterol Clin Biol. 1989 Apr;13(4):343-52.

Biocare Medical Announces Launch of a New p16 INK4a IVD Monoclonal Antibody for use in Immunohistochemistry

New p16 INK4a [BC42] monoclonal antibody with exceptional sensitivity and specificity

San Francisco, CA, September 3, 2019 – Biocare Medical, LLC, a leading provider of innovative, automated immunohistochemistry (IHC) instrumentation and reagents, announces the release of a new mouse monoclonal antibody, p16 INK4a, for in vitro diagnostic (IVD) use in the qualitative identification of the p16 INK4a protein by immunohistochemistry (IHC) in formalin-fixed paraffin-embedded (FFPE) human tissues.

“Our BC42 clone of p16 INK4a antibody offers equally exceptional staining results as the current E6H4 clone of p16 INK4a antibody offered on the market,” said Jason Ramos, Ph.D., Vice President (Reagent Research and Development) of Biocare Medical. “Notably, clone BC42 showed nearly identical specificity and sensitivity, along with staining pattern, in cervical adenocarcinoma, cervical intraepithelial neoplasia (CIN), cervical squamous carcinoma, head and neck cancer, and endometrium carcinoma.”

The adjunctive use of p16 IHC is shown to aid in more accurate and reproducible diagnosis in the evaluation of cervical biopsies. We believe that our new p16 INK4a IVD antibody will be a cost-effective IHC solution to the pathology community, which translates to more patients receiving the right treatment.

Biocare’s p16 INK4a antibody [BC42] is available in a concentrate IVD format to support titration by end-users as well as a predilute IVD format at a pre-optimized concentration and is available for immediate sale within the domestic US and European Union.

For more information, please visit: www.biocare.net

Cancer Awareness – Gallbladder Cancer Facts

Approximately 12,000 men and women in the United States are diagnosed with gallbladder cancer annually, leading to an annual estimated 4,000 deaths.1 Gallbladder and other biliary cancers are comparatively rare in the United States, with about 0.7% of new cancer cases classified as gallbladder, contributing approximately 0.6% of cancer deaths yearly.1 Worldwide, gallbladder and other biliary cancers are the twenty-second most frequently diagnosed cancer and the eighteenth leading cause of cancer death, with an annual estimated 219,400 cases and 165,100 deaths.2

Gallbladder carcinoma (GBC) is predominantly found in women (female to male ratio, 3-4: 1), which may be related to increased incidence of gallstones in women.3 In addition to gallstones and gender, there are other risk factors that may influence the development of GBC:4

• Gallbladder polyps: Growths that may form as a result from an embedded gallstone or inflammation.
• Age:
Most patients diagnosed with GBC are in the sixth or seventh decade of life.
• Ethnicity: In the United States, Hispanic and Native Americans have a higher rate of gallbladder cancer than other ethnic groups.
• Smoking: Tobacco use may elevate the risk of death from gallbladder cancer dose-dependently among both men and women.
• Family history: Family history of GBC slightly increases risk of developing GBC.

GBC is a poor prognosis malignancy since it usually presents at a very advanced stage. Early detection of GBC is often difficult because symptoms mimic benign gallbladder diseases, such as gallstones and biliary colic.5 Differentiation of GBC versus non-malignant gallbladder disease is critical to accurate diagnosis and treatment. There have been many immunomarkers reported to be expressed in GBC and not expressed in normal/benign gallbladder: CA 19-9, CEA, Mucin 5AC, S100P, IMP3, GLUT-1, p53, and CDX2.6,7,8,9

As part of our promise of “Fighting Cancer, One Slide at a Time,” Biocare Medical is proud to offer key high-quality immunohistochemistry (IHC) antibodies that aid in accurate classification of gallbladder and other biliary tumors.

Key Antibodies for Gallbladder and Biliary Cancer

Product Name Clone Catalog Number
CA 19-9 BC/121SLE CM 123; PM 123
Carcinoembryonic Antigen (CEA {M}) COL-1 CM 058; PM 058
Mucin 5AC 45M1 CM 231
S100P N/A ACI 3010; API 3010
IMP3 (RM) EP286 ACI 3180; API 3180
GLUT-1 SPM498 CM 408; PM 408
p53 EP9 CME 298; PME 298; IP 298
p53 Tumor Suppressor Protein DO-7 CM 042; PM 042
CDX2 [BC39] BC39 ACI 3184; API 3184; AVI 3184
CDX2 (RM) EP25 ACI 3144; API 3144

Clinical References:

1. Siegel RL, Miller KD, Jemal A. CA Cancer J Clin. 2017 Jan;67(1):7-30.
2. Bray F, et al. CA Cancer J Clin. 2018 Nov;68(6):394-424.
3. Giang TH, et al. Diagn Pathol. 2012 Jan 27;7:10.
4. https://www.cancer.net/cancer-types/gallbladder-cancer/risk-factors
5. https://www.cancer.org/cancer/gallbladder-cancer/detection-diagnosis-staging
6. Hughes NR, Bhathal PS. J Clin Pathol. 2013 Mar;66(3):212-7.
7. Lin F, Chen ZE, Wang HL. Arch Pathol Lab Med. 2015 Jan;139(1):24-38.
8. Xiong L, et al. J Surg Oncol. 2012 Jan;105(1):97-103.
9. Park SY, et al. Oncol Rep. 2009 Sep;22(3):649-57.

Biocare Achieves ISO 13485:2016 Certification

Biocare Medical has achieved ISO 13485:2016 Certification as of February 20, 2019.

The quality management system is applicable to:

  • Design, manufacture and distribution of in vitro diagnostic (IVD), immunohistochemistry reagents/kits, and design, manufacture, distribution, installation and service of general purposes laboratory equipment medical devices.
  • Additional site1: Manufacture, installation and service
  • Additional site2: Design and manufacture

Download our ISO 13485:2016 Certificate of Registration Here.

Beyond the HIER 30-Slide Barrier

Beyond the HIER 30-Slide Barrier

The adoption of heat induced epitope retrieval, or HIER, as a standard enhancement technique for IHC has framed the use of IHC as a valuable tool for the examination of formalin fixed, paraffin embedded (FFPE) tissue for the past few decades.1 The mechanical requirements of heat induced epitope retrieval protocols framed the maximum performance features of automated IHC staining instruments in recent years as well. Those constraints have limited the throughput capabilities of automated IHC staining platforms, until now.

Would you like to learn more about HIER?

As the name implies, heat induced epitope retrieval (HIER), also known as Antigen retrieval, is driven by the application of sustained heat and specially formulated buffers to glass slides and the affixed FFPE tissue. The high, sustained heat required for the HIER process can be generated by manual methods such as steamers, heat baths, microwave ovens, or pressure cookers.2 For automated IHC instruments that support on-board HIER, indirect heat applied by under-slide heaters are commonly employed to provide the sustained high temperatures required for the HIER process.3 However, the physics of generating and maintaining high temperatures across dozens of slide heaters in parallel imparts significant electrical demands on the power supply for the instrument. The maximum power draw from standard laboratory wall outlets (typically 1800W) imposes a threshold to the heat output that any given instrument can sustain for an extended period of time (Red section Figure 1).

Figure 1: Power usage of current Automated IHC Staining Platforms

Laboratories using automated IHC staining equipment have become accustomed to this HIER processing limit in the form of a “30-slide barrier;” in other words, the lack of enough input power to apply high heat to more than 30 slides at once. Many IHC labs prefer the workflow advantages of automated staining, including on-board automation of the HIER process. However, the 30-slide barrier curtails those advantages by limiting the parallel processing of slides and ultimately impacting the overall daily slide throughput of the laboratory. To break the 30-slide barrier, a new approach to the power management of the automated HIER process was required.

In a recent article, Dr. David Basiji outlines how a rechargeable Lithium Ion Battery can be used to store extra input energy for automated IHC protocols, boosting the parallel slide processing capability for HIER, then recharge when the IHC protocol’s power demands are low (Figure 2).

Figure 2: Power usage of Automated IHC Staining Platform with Hybrid Lithium Ion Power

Even more recently, Biocare Medical harnessed that power in the design of the new VALENT automated staining platform, a fully open, fully automated IVD staining platform for IHC laboratories. VALENT employs battery hybrid power to maximize parallel slide processing for HIER and break the 30-slide barrier, providing laboratories with unparallel throughput for automated IHC applications.

For a more detailed explanation of how to break the 30-slide barrier with Biocare’s new VALENT platform, learn more about the Power of Advanced Automation

References: 1. Shi, SR et al book: “Antigen Retrieval Immunohistochemistry Based Research and Diagnostics.” 2. Ramos-Vara JA, Miller MA. Vet Pathol. 2014 Jan;51(1):42-87. 3. Prichard JW. Arch Pathol Lab Med. 2014 Dec;138(12):1578-82.

BIOCARE MEDICAL UNVEILS THE VALENT® – THE FIRST EVER OPEN, FULLY AUTOMATED IVD STAINING PLATFORM

The VALENT, the Market’s Only Open, Fully Automated IVD Platform that Delivers Industry-Leading Throughput and Quality to Clinical, Pharmaceutical and Research Customers

San Francisco, CA, January 24, 2019 – Biocare Medical, LLC, a leading provider of innovative, automated immunohistochemistry (IHC) instrumentation and reagents, announces the release of the VALENT IVD (in vitro diagnostic) automated staining platform.

VALENT is the industry’s first fully automated, open platform, merging high-throughput and quality staining with a powerful and intuitive user interface. VALENT overcomes the limitations of closed systems with its unique open platform, allowing reagents from multiple sources and providing top-tier IHC results. VALENT transforms clinical, pharmaceutical and research laboratories by providing an easy-to-use fully automated platform, 48-slide capacity, multiplex IHC capability, and high-quality staining.

“We work closely with customers, in all different testing environments, to maintain a deep understanding of their job demands and requirements,” said Morgan Porter, Chief Operating Officer of Biocare Medical. “That’s why we’re so thrilled to introduce the VALENT to the market and provide our customers with the most innovative staining platform available in the industry today.”

“The on-line HIER feature of Biocare’s VALENT enables walkaway freedom for the histotech,” said Cheryl Bodden, Histology Laboratory Manager at USF Health Labs.

Increase Efficiency and Flexibility

With VALENT, the IHC protocol is completely automated; performing fast, non-toxic online deparaffinization and utilizing a novel, patent-pending, continuous antigen retrieval dispense technology. With VALENT, Biocare offers a full line of high quality, ready-to-use reagents that have been optimized for maximum performance supporting convenient load-and-go capability, and ultimately enhancing laboratory workflow. The open platform of VALENT enables users to apply enzyme pre-treatments, antibodies, detections, or chromogens from any source. These combined capabilities significantly increase laboratory efficiency, flexibility and turn-around time; freeing up valuable time and resources.

Break the 30-slide Barrier

VALENT breaks the 30-slide barrier, processing 48 slides simultaneously and supporting unparalleled throughput with minimal hands-on time. VALENT employs a high capacity lithium battery to boost the antigen retrieval process and safeguard staining runs in the event of power loss. By enabling users to process more slides per run, safeguard against power fluctuations and provide onboard backup power, VALENT technicians enjoy peace of mind knowing their runs will be completed on time, every time.

Outpace the Competition

In addition to high-quality results, ease-of-use, increased efficiency, and reduced costs, VALENT offers several key features that enable laboratories to stay ahead in this highly competitive space:

Convenient and Intuitive
VALENT is equipped with an array of automatic sensors, minimizing errors before and during runs. The software has an intuitive user interface, placing frequently used functions in a color-coded block on the main screen. The onboard mixing capability of VALENT allows for a walkaway operation and with a 50µL reagent vial dead volume, it also minimizes precious reagent loss, saving money. The convenience of separating hazardous from non-hazardous waste also reduces disposal costs.

Self-Leveling
A level slide and instrument are critical for reagents to be evenly dispensed, ensuring consistently stained, high-quality IHC results. VALENT utilizes a dual-axis inclinometer which, when combined with motorized legs, allows it to self-level. The electronic inclinometer eliminates the reliance upon traditional, subjective levels while offering traceability for end-user record-keeping and regulatory compliance. With motorized legs that can be height adjusted, VALENT also provides optimal user ergonomics.

Self-Cleaning
VALENT performs several self-cleaning techniques to improve stain quality and reduce valuable time that technicians would otherwise spend cleaning. Automated cleaning processes ensure optimal performance and reduce variability. Automated probe and wash station cleaning, as well as weekly automated cleaning routines, maximize staining results and efficiency.

Simultaneous Multiplex IHC
Biocare Medical is the proven leader in simultaneous Multiplex IHC, allowing for visualization of multiple antigens on a single slide. VALENT is designed with simultaneous Multiplex IHC capability, enabling laboratories to save time, money, and precious patient tissue samples.

VALENT is available for immediate sale domestically and includes world-class training and support from Biocare Medical’s highly skilled Education and Customer Care teams. For more information or to schedule a free demo, please visit: www.biocare.net/VALENT


About Biocare Medical

Biocare Medical is a global leader in solutions for cancer research and diagnostics, providing: world-class reagents, including tissue-conserving simultaneous Multiplex antibody cocktails and detections; renowned Customer Care; and a comprehensive suite of advanced instrumentation for IHC, molecular, and histology testing. Customers include clinical anatomic pathology laboratories, pharmaceutical companies, CROs, and biotechnology companies as well as academic, government, military, and other non-profit laboratories. Biocare’s reagent portfolio includes primary antibodies, Multiplex IHC, and FISH probes for target indications. Biocare also offers a unique line of polymer detections for clinical, human, and animal research that deliver high sensitivity and exceptionally low background. The Company’s advanced platforms of semi and fully-automated instrumentation have been designed to meet every need from high throughput clinical diagnostics to flexible research requirements. Biocare Medical’s corporate headquarters and operations are based in the San Francisco Bay Area with a global distribution network.

E-COMMERCE Now Live!

E-commerce Now Live!

Biocare Medical is excited to announce that our new e-commerce platform is now online! We’ve made some significant changes to our online experience that we hope it will not only improve how you interact with us but save you time as well.

  • Pay by Credit or Debit Card anytime
  • Save Your Payment Method for Future Purchases
  • Flat Rate Shipping, $49 – 2 Day, $59 Standard Overnight
  • Order History – Look up all of your previous orders 24/7 with tracking information
  • Auto Search – search by product title, full or partial catalog number
  • Tax Calculations specific to your account

We look forward to hearing your feedback and hope you enjoy these streamlined features.

Biocare Announces Strategic Investment from Excellere Partners

Excellere Partners has made an investment in Pacheco, California-based Biocare Medical, a provider of immunohistochemistry instrumentation, as well as a full range of reagents for IHC and molecular testing. No financial terms were disclosed.

PRESS RELEASE

Denver, CO, August 25, 2017 – Excellere Partners, a Denver-based private equity firm focused on partnering with entrepreneurs and management teams, announced today that it has made a strategic investment in Biocare Medical (“Biocare”), a leading provider of immunohistochemistry (IHC) instrumentation, as well as a full range of reagents for IHC and molecular testing. The Biocare partnership represents the first platform investment in Excellere Capital Fund III, L.P.

An innovator in the sector, Biocare is a market leader in simultaneous Multiplex IHC tests, which provide increased confidence at critical diagnostic decision points, improving patient therapy while accelerating turnaround time. “We’re thrilled to have the opportunity to partner with Roy Paxton Yih and the entire Biocare team, and are excited to support their vison for building a best-in-class industry leader focused on IHC and molecular diagnostic products,” said Ryan Glaws, Partner at Excellere. “We identified the reagents and diagnostics products sector several years ago as an attractive area in which to execute Excellere’s value creation strategy. We have dedicated significant resources to pursuing a reagent platform that has a differentiated product offering, global customer base, commitment to R&D, and a passionate leadership team. In Biocare, we have found both an exceptional business as well as a proven management team,” continued Mr. Glaws.

Biocare’s partnership with Excellere will provide the strategic and financial resources to enhance and accelerate the company’s growth opportunities. To this end, Biocare management and Excellere intend to implement a multi-faceted growth strategy comprised of foundational investments that further enhance Biocare’s scalable infrastructure; identified organic growth initiatives in existing and new markets; and complementary strategic partnerships with other leading reagent and diagnostic businesses.

“We have an outstanding opportunity to partner with Excellere, which has a proven track record of supporting founder-led businesses in achieving transformative growth. Over the last 20 years we have not only built a strong and growing company, but more importantly, have developed innovative products that enhance the disease diagnosis and monitoring process andultimately save lives. While we had many options, we chose Excellere as our partner based on their track record and passion for supporting emerging growth companies. We believe that our product suite and service model uniquely position Biocare to meet the evolving demands of clinicians and researchers across the globe,” said Roy Paxton Yih, Biocare co-founder and Chief Executive Officer.

“This partnership is perfectly aligned with our firm’s founding philosophy to invest in entrepreneurial healthcare businesses that are patient-centric, while also creating value for the clinicians, institutions, and other stakeholders in the healthcare ecosystem. Together, Biocare management and Excellere will further strengthen the company’s presence, not only in the U.S., but in other attractive markets by partnering with leading reagent and diagnostic tools businesses as well as expanding the company’s product offering.” Mr. Glaws explained.

About Biocare
Biocare is a market leader in IHC and molecular diagnostic reagents, including simultaneous Multiplex IHC tests that provide increased confidence at critical diagnostic decision points, positively influencing patient therapy while accelerating turnaround time. The company’s customers include clinical and hospital laboratories, pharmaceutical companies, and biotechnology companies as well as academic, government, military, and other nonprofit laboratories. Biocare offers an expanding portfolio of integrated products to address the rapidly growing cancer and infectious disease diagnostic and research markets with novel tissue immunohistochemistry and in situ hybridization methods. The company is headquartered in Pacheco, CA, and has a global distribution network. Visit www.biocare.net to learn more.

About Excellere Partners
Excellere Partners is a Denver-based private equity firm with $1.36 billion of committed capital across Fund I, Fund II and Fund III, specializing in partnering with entrepreneurs and management teams. The firm employs a proven research-driven, top down investment strategy, and supports its entrepreneurs and management teams with a proprietary value creation process designed to enhance corporate and operational infrastructure for scalability and growth. Excellere’s investments are focused on differentiated and growth oriented companies positioned to benefit from industry consolidation and favorable macro-economic and demographic trends. Excellere’s targeted industry sectors include: healthcare services and products; energy, power and infrastructure services and products; industrial technology, specialty chemicals; and business services. For more information about Excellere, please visit https://www.excellerepartners.com

For More Information Visit: https://www.pehub.com/2017/08/excellere-partners-invests-in-biocare-medical/

HPV Probes Now Available from Biocare Medical

Biocare Medical, LLC is pleased to announce the availability of a comprehensive line of HPV probes for in situ hybridization. Each digoxigenin-labeled individual probe is designed to detect HPV DNA viral subtypes 6, 11, 16, 18, 31 or 51.

Almost 80 million Americans are infected with Human Papilloma Virus (HPV), with about 14 million becoming newly infected each year. HPV is considered to be the most common sexually transmitted infection. Although relatively rare, cervical cancer resulting from HPV infection with so-called “high risk” viral subtypes afflicts over 11,000 women every year in the United States. Low risk HPV subtypes are responsible for 360,000 annual cases of genital warts and a smaller number of recurrent respiratory papillomatosis cases.

“With the introduction of our line of HPV probes, Biocare Medical strives to improve the molecular diagnostic tools available to pathologists, as well as advance diagnostic confidence. This is especially critical in cases of discriminating HPV-positive vs. HPV-negative oropharyngeal squamous cell carcinoma, where a correct diagnosis reduces therapy-related morbidity,” says Dr. David Tacha, Chief Scientific Officer of Biocare Medical.

About Biocare Medical
Biocare Medical, LLC is an innovator in developing and supplying world class automated immunohistochemistry (IHC) instrumentation and the full range of reagents for IHC and ISH lab testing. Biocare Medical is the market leader in simultaneous Multiplex IHC and antibody development, which aids in the assessment of clinical cases and accelerates turnaround time. The company’s customers include clinical histology laboratories, pharmaceutical companies, CROs, and biotechnology companies as well as academic, government, military, and other non-profit laboratories. Biocare Medical offers an expanding portfolio of integrated products to address the rapidly growing cancer and infectious disease diagnostic and research markets using tissue immunostaining and in situ hybridization methods. Biocare Medical is headquartered and has manufacturing facilities in Concord, California, and has a global distribution network. For more information, please visit www.biocare.net.