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Hairy Cell Leukemia [DBA.44]
$248.00 – $558.00
Description
Product Description
Hairy Cell Leukemia is a rare hematological malignancy in which B-cell lymphocytes are produced in excessive quantities. Hairy Cell Leukemia is characterized by small lymphocytes bearing fine hair-like cytoplasmic projections with infiltration of reticuloendothelial organs such as lymphoid organs and bone marrow.15,16 This mouse monoclonal antibody, also referred to as DBA.44, may be used in immunohistochemistry (IHC) testing using bone marrow biopsies to identify Hairy Cell Leukemia over low grade B-cell lymphomas.17 DBA.44 shows a high and consistent reaction with tissue infiltrates of Hairy Cell Leukemia, with a detection rate of 96%.18
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Specifications
Specifications
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Datasheet & SDS
| Download Data Sheet |
| Download RUO Data Sheet |
| Download SDS Sheet |
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References
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7. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.
8. CLSI Quality Standards for Design and Implementation of Immunohistochemistry Assays; Approved Guideline-Second edition (I/LA28-A2) CLSI Wayne, PA USA (www.clsi.org). 2011
9. College of American Pathologists (CAP) Certification Program for Immunohistochemistry. Northfield IL. Http://www.cap.org (800) 323- 4040.
10. O’Leary TJ, Edmonds P, Floyd AD, Mesa-Tejada R, Robinowitz M, Takes PA, Taylor CR. Quality assurance for immunocytochemistry; Proposed guideline. MM4-P. National Committee for Clinical Laboratory Standards (NCCLS). Wayne, PA. 1997;1-46.
11. Koretzik K, Lemain ET, Brandt I, and Moller P. Metachromasia of 3- amino-9-ethylcarbazole (AEC) and its prevention in Immunoperoxidase techniques. Histochemistry 1987; 86:471-478.
12. Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983; 14:767.
13. Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen: a possible source of error in immunohistochemistry. AmJ Clin Path 1980; 73:626.
14. Herman GE and Elfont EA. The taming of immunohistochemistry: the new era of quality control. Biotech & Histochem 1991; 66:194.
15. Lipták J, Piukovics K, Borbényi Z, et al. A comprehensive immunophenotypic marker analysis of hairy cell leukemia in paraffinembedded bone marrow trephine biopsies–a tissue microarray study. Pathol Oncol Res. 2015 Jan;21(1):203-11.
16. Getta BM, Park JH, Tallman MS. Hairy cell leukemia: Past, present and future. Best Pract Res Clin Haematol. 2015 Dec;28(4):269-72.
17. Kreitman RJ. Hairy cell leukemia: present and future directions. Leuk Lymphoma. 2019;60(12):2869-2879.
18. Sherman MJ, Hanson CA, Hoyer JD. An assessment of the usefulness of immunohistochemical stains in the diagnosis of hairy cell leukemia. Am J Clin Pathol. 2011 Sep;136(3):390-9.
