E-cadherin (Mouse)

Product Description

E-cadherin mouse antibody is a transmembrane glycoprotein that mediates epithelial cell-cell adhesion. The loss of E-cadherin can result in the disruption of cell clusters. It has been postulated in literature that E-cadherin may function as a tumor suppressor protein. Several studies have associated the loss of E-cadherin with metastasis and poor prognosis in invasive breast cancer. Additional studies have suggested that E-cadherin can help differentiate between ductal and lobular neoplasms of the breast. E-cadherin immunostaining has also been shown to be an independent predictor of disease progression in bladder cancer.

Specifications

1. Yoshida R, et al. Int J Oncol. 2001 Mar; 18(3):513-20.
2. Byrne RR, et al. J Urol. 2001 May; 165(5):1473-9.
3. Acs G, et al. Am J Clin Pathol. 2001 Jan; 115(1):85-98.