The Src-related protein tyrosine kinases Lck p56 and Fyn p59 are critically involved in T-cell antigen receptor (TCR/CD3-triggered activation. T-lymphocytes also express a second class of non-receptor protein tyrosine kinases, which includes Syk p70 and ZAP p72. In contrast, the ZAP p70 kinase was insufficient unless it was coaggregated with a Fyn p59-containing chimera, suggesting that regulation of ZAP p70 activity may require a functional interaction with Src family kinases. In a study, an investigation into whether the expression of ZAP-70 with chronic lymphocytic leukemia (CLL) cells correlated with the immunoglobulin heavy-chain variable-region (IgVH) mutational status, disease progression, and survival. The mutational status of (IgVH) genes in the leukemic cells of chronic lymphocytic leukemia (CLL) is an important prognostic factor in the disease. Studies have shown patients with CCL expression of ZAP-70 that correlated with IgVH mutational status, disease progression, and survival. Immunohistochemical assays for ZAP-70 expression that can be applied clinically may yield important prognostic information for CLL patients.
Human, Mouse, Rat
Nuclear blush and cytoplasmic
1. Crespo et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med. 2003 May 1;348(18):1764-75.
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