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Zeta-associated protein-70 (ZAP-70 antibody) is a tyrosine kinase normally expressed by natural killer cells and T cells. Several studies have indicated a correlation between ZAP-70 expression and immunoglobulin heavy-chain variable-region (IgVH) mutational status in the leukemic cells of chronic lymphocytic leukemia (CLL), with ZAP-70 suggested as a surrogate marker for IgHV mutational status. The mutational status of IgVH genes in CLL is an important prognostic factor in the disease and ZAP-70 overexpression indicates an unfavorable disease course in terms of progression and overall survival.
Human, Mouse, Rat
BC.2F3.2, Biocare Clone
Nuclear blush and cytoplasmic
1. Crespo et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med. 2003 May 1;348(18):1764-75.
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