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During the malignant transformation of cervical squamous cells from normal to malignant there are two key events. The first is infection by high risk sub-types of the human papilloma virus (HPV), followed by chromosomal instability characterized by an increase in chromosome copy number (polysomy) and by TERC gene amplification. The genetic changes are associated with high-grade intraepithelial neoplasia and progression to invasive carcinoma1. The use of FISH to detect TERC amplification has been shown to be an effective tool in a differential diagnosis of cervical disorders2. High grade lesions have been reported to show amplification in up to 83% of cases vs approx. 43% of low grade cases3.