p120 Catenin

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p120 is a proliferation-associated nucleolar protein found in most human malignant tumors, but not in resting normal cells. In colorectal cancer the altered localization of p120 Catenin corresponds with loss of cytoplasmic localization of E-cadherin. Studies have shown accurate categorization of ductal vs. lobular neoplasia in the breast was achieved with p120 staining. p120 expression further clarifies the separation of low-grade ductal carcinoma in situ from lobular neoplasia. Studies also have shown that altered expression of p120 Catenin antibody predicts poor outcome in invasive breast cancer.

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

98/pp120

Isotype

IgG1

Antigen

p120 catenin

Localization

Cytoplasmic and membrane

Positive Control

Breast cancer

1. Talvinen K, et al. Altered expression of p120catenin predicts poor outcome in
invasive breast cancer. J Cancer Res Clin Oncol. 2010 Sep; 136(9):1377-87.
2. Yu J, Bhargava R, Dabbs DJ. Invasive lobular carcinoma with extracellular mucin
production and HER-2 over expression: a case report and further case studies. Diagn
Pathol. 2010 Jun 15; 5:36. Free PMC Article
3. Chivukula M, et al. Pleomorphic lobular carcinoma in situ (PLCIS) on breast core
needle biopsies: clinical significance and immunoprofile. Am J Surg Pathol. 2008 Nov;
32(11):1721-6.
4. Esposito NN, Chivukula M, Dabbs DJ. The ductal phenotypic expression of the Ecadherin/catenin complex in tubulolobular carcinoma of the breast: an
immunohistochemical and clinicopathologic study. Mod Pathol. 2007 Jan; 20(1):130-8.
Epub 2006 Nov 24.
5. Dabbs DJ, Bhargava R, Chivukula M. Lobular versus ductal breast neoplasms: the
diagnostic utility of p120 catenin. Am J Surg Pathol. 2007 Mar; 31(3):427-37.
6. Bellovin DI., et al. Altered localization of p120 catenin during epithelial to
mesenchymal transition of colon carcinoma is prognostic for aggressive disease.
Cancer Res. 2005 Dec 1; 65(23):10938-45.
7. Anastasiadis PZ, Reynolds AB. The p120 catenin family: complex roles in adhesion,
signaling and cancer. J Cell Sci. 2000 Apr; 113 (Pt 8):1319-34.
8. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22,
Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove
Azide Salts.”
9. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory
workers from occupationally Acquired Infections; Approved guideline-Third Edition
CLSI document M29-A3 Wayne, PA 2005

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