p120 Catenin

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p120 is a proliferation-associated nucleolar protein found in most human malignant tumors, but not in resting normal cells. In colorectal cancer the altered localization of p120 Catenin corresponds with loss of cytoplasmic localization of E-cadherin. Studies have shown accurate categorization of ductal vs. lobular neoplasia in the breast was achieved with p120 staining. p120 expression further clarifies the separation of low-grade ductal carcinoma in situ from lobular neoplasia. Studies also have shown that altered expression of p120 Catenin antibody predicts poor outcome in invasive breast cancer.

Intended Use


Species Reactivity



Mouse Monoclonal






p120 catenin


Cytoplasmic and membrane

Positive Control

Breast cancer

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immunohistochemical and clinicopathologic study. Mod Pathol. 2007 Jan; 20(1):130-8.
Epub 2006 Nov 24.
5. Dabbs DJ, Bhargava R, Chivukula M. Lobular versus ductal breast neoplasms: the
diagnostic utility of p120 catenin. Am J Surg Pathol. 2007 Mar; 31(3):427-37.
6. Bellovin DI., et al. Altered localization of p120 catenin during epithelial to
mesenchymal transition of colon carcinoma is prognostic for aggressive disease.
Cancer Res. 2005 Dec 1; 65(23):10938-45.
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workers from occupationally Acquired Infections; Approved guideline-Third Edition
CLSI document M29-A3 Wayne, PA 2005


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