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Research into myeloid disorders including myelodysplastic syndrome (MDS) and acute myeloid dysplasia (AML) has shown frequent monosomy of chromosome seven as well as deletion of the 7q region1,2.
Further, it has been shown that this deletion of the 7q region on the long arm of chromosome 7 is not only a consistent finding in myeloid disorders but is also invariably associated with a poor prognosis3 .
Colorectal, Gastric, Lung
1. Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases. Le Beau MM, Espinosa R 3rd, Davis EM, Eisenbart JD, Larson RA, Green ED. Blood. 1996 ; 88 (6) : 1930-1935.
2. Cytogenetic clonality analysis in myelodysplastic syndrome: monosomy 7 can be demonstrated in the myeloid and in the lymphoid lineage. van Lom K, Hagemeijer A, Smit E, Hählen K, Groeneveld K, Löwenberg B. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1995 ; 9 (11) : 1818-1821.
3. Delineation of Multiple Deleted Regions in 7q in Myeloid Disorders. Sabrina Tosi, Stephen W. Scherer, Giovanni Giudici, Barbara Czepulkowski, Andrea Biondi, and Lyndal Kearney. Genes, Chromosomes & Cancer 25:384–392 (1999)
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.