IGH gene rearrangements are considered to be one of the classical cytogenetic gene aberrations associated with numerous cancers such as: Chronic lymphocytic leukemia (CLL), Multiple Myeloma (MM), and Non-Hodgkin lymphoma1,2,3. The t(11;14)(q13;q32) translocation results in the CCND1 gene being inserted into the heavy chain (IGH) locus resulting in over production cyclin D1 protein4. This is considered by many to be the hallmark cytogenetic event associated with mantle cell lymphoma.
1. Cavazzini, Francesco, Lara Rizzotto, Olga Sofritti, Giulia Daghia, Francesca Cibien, Sara Martinelli, Maria Ciccone, Elena Saccenti, Melissa Dabusti, Abbas Awad Elkareem, Antonella Bardi, Elisa Tammiso, Antonio Cuneo, and Gian Matteo Rigolin. “Clonal Evolution including 14q32/translocations in Chronic Lymphocytic Leukemia: Analysis of Clinicobiologic Correlations in 105 Patients.” Leukemia & Lymphoma (2011): 83-88.
2. Moreau, P. “Recurrent 14q32 Translocations Determine the Prognosis of Multiple Myeloma, Especially in Patients Receiving Intensive Chemotherapy.” Blood (2002): 1579-583. Print.
3. Aamot, Hege Vangstein, Merete Bjornslett, Jan Delabie, and Sverre Heim. “T(14;22)(q32;q11) in Non-Hodgkin Lymphoma and Myeloid Leukaemia: Molecular Cytogenetic Investigations.” British Journal of Haematology (2005): 845-51.
4. Aventín, Nomdedéu, Briones, Espinosa, Bordes, and Sierra. Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle lymphoma with normal chromosomes 11 and 14. J Clin Pathol 2003;56:798–800
5. Clinical and Laboratory Standards Institute (CLSI). Protection of laboratory workers from occupationally acquired infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.