Vimentin is the main intermediate filament protein in mesenchymal cells. Vimentin antibody shows no cross-reactivity with other closely related intermediate filament proteins such as Desmin and GFAP. Vimentin may be useful as an epithelial-mesenchymal transition (EMT) marker, giving an indication of tumor progression and potential for metastasis and is of value in the differential diagnosis of undifferentiated neoplasms including melanoma and sarcoma. Vimentin can also serve as an internal control for formalin-fixed tissues that are over-fixed.
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