Uroplakin II

Product Description

Uroplakin II is a 15 kDa protein component of urothelial plaques, which enhance the permeability barrier of the urothelium. 15 Uroplakin II [BC21] is a highly specific antibody that may be useful in identifying tumors of urothelial origin.

Specifications

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Wu XR, et al. Uroplakins in urothelial biology, function, and disease. Kidney Int. 2009 Jun; 75(11):1153-65.
2. Wu X, et al. Uroplakin II as a promising marker for molecular diagnosis of nodal metastases from bladder cancer: comparison with cytokeratin 20. J Urol. 2005 Dec; 174(6):2138-42.
3. Lu JJ, et al. Detection of circulating cancer cells by reverse transcription-polymerase chain reaction for uroplakin II in peripheral blood of patients with urothelial cancer. Clin Cancer Res. 2000 Aug; 6(8):3166-71.
4. Li SM, et al. Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder. J Urol. 1999 Sep; 162(3 Pt 1):931-5.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.