Treponema pallidum

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Spirochete (Treponema pallidum) is the causative agent of syphilis. Spirochete can now be successfully localized with a treponema pallidum antibody using immunohistochemical techniques in formalin-fixed, paraffin-embedded (FFPE) tissue. In the past, localization of the spirochete agent was achieved with silver stains such as Steiner’s and/or Warthin-Starry. The spirochete antibody consists of a rabbit purified IgG fraction that is highly specific. Treponema pallidum antibody also cross-reacts with burgdorferi (Lyme disease).

Species Reactivity



Rabbit Polyclonal






Treponema pallidum (Spirochete)


Corkscrew bacteria

Positive Control

Spirochete infected tissues

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1. Hoang MP, High WA, Molberg KH. Secondary syphilis: a histologic and immunohistochemical evaluation. J Cutan Pathol. 2004 Oct;31(9):595-9.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.


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