TP53 is the gene which encodes for the p53 tumor suppressor protein. TP53 is activated in many forms of cellular stress including carcinogenesis and exerts multiple anti-proliferative functions1. TP53mutations are one of the most common findings in many human cancers and has been proposed as an effective measure of prognosis2.
Typically the presence of a specific mutation has been correlated with a shorter survival or poor response to treatment. Multiple breast cancer studies have all shown that there was a clear association between mutation and bad prognosis3.