S100P

Product Description

The Biocare S100P antibody recognizes placental S100 binding protein, a member of the S100 family of proteins originally identified in the placenta and later associated with cancer.^15,17 Members of the S100 protein family function as extracellular and/or intracellular regulators of diverse cellular processes and are implicated in various human pathologies. Functional studies indicate that S100P exerts its biological activities either through extracellular signaling via the RAGE receptor—resulting in increased proliferation and survival—or through intracellular interaction with ezrin, leading to increased cell migration and metastasis.¹⁸

S100P expression has been detected in tumor cell lines and tissues from breast, prostate, pancreas, lung, and colon, where it is associated with a malignant phenotype, hormone independence, and resistance to chemotherapy. Overexpression of S100P has been shown to promote tumorigenesis and metastasis in diverse cancer models. Recent studies have demonstrated high expression of S100P in poorly differentiated bladder cancers, with localization in both the cytoplasm and nucleus. S100P is negative in the vast majority of renal cell and prostate carcinomas, making it a useful marker in the differential diagnosis of bladder, prostate, and renal cell carcinomas. Additionally, S100P has shown utility in the diagnosis of adenocarcinoma of the pancreas in fine-needle aspiration biopsy specimens.^{15- 19}

Specifications

1. Esheba GE, et al. Expression of the urothelial differentiation markers GATA3 and placental S100 (S100P) in female genital tract transitional cell proliferations. Am J Surg Pathol. 2009 Mar; 33(3):347-53.
2. Chuang AY, et al. Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma. Am J Surg Pathol. 2007 Aug; 31(8):1246-55.
3. Higgins JP, et al. Placental S100 (S100P) and GATA-3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol. 2007 May; 31(5):673-80.
4. Gibadulinova A, et al. Transcriptional regulation and functional implication of S100P in cancer. Amino Acids. 2011 Oct; 41(4):885-92.
5. Deng H, et al. Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens. Am J Clin Pathol. 2008 Jan; 129(1):81-8.
6. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
7. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.