ROS1 (6q22) Break Apart Orange/Green

Product Description

The ROS1 (6q22) Break Apart FISH probe is designed to detect a chromosomal rearrangement involving the ROS1 gene located on chromosome 6q22. The ROS1 gene encodes a tyrosine kinase receptor. Chromosomal rearrangements involving ROS1 have been implicated in multiple cancer indications (1,2) and has been identified as an oncogenic driver in Non-small cell lung cancer (3). Preclinical data indicates that tumors harboring this genetic rearrangement are sensitive to Crizotinib, a ROS1 kinase inhibitor (1).

Specifications

1. Bergethon, Kristin, et al. “ROS1 Rearrangements Defines a Unique Molecular Class of Lung Cancers.” Journal of Clinical Oncology (2012): 863-70.
2. Davies, Kurtis, et al. “Identifying and Targeting ROS1 Gene Fusion in Non-Small Cell Lung Cancer.” Human Cancer Biology 18.17 (2012): 4570-579.
3. Stumpfova, M., P. A. Janne. “Zeroing in on ROS1 Rearrangements in Non-Small Cell Lung Cancer.” Clinical Cancer Research (2012): 4222- 224.
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.