Prostate Specific Antigen antibody (PSA) is a chymotrypsin-like serine protease (kallikrein family) produced by the prostate epithelium. PSA can be used as a screening marker for differentiating high-grade prostate adenocarcinoma from high-grade urothelial carcinoma. PSA may also be a useful aid to confirm prostatic acinar cell origin in primary and metastatic carcinomas and to rule out non-prostatic carcinoma mimics. PSA can be a valuable tool in the diagnostic evaluation of metastatic adenocarcinoma of unknown primary origin in males.
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