NKX3.1

Product Description

NKX3.1 is a protein found in humans and is encoded by the NKX3.115 gene located on chromosome 8.¹⁵ The homeodomain containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner.^15,16 NKX3.1 protein has been found to be positive in the vast majority of primary prostatic adenocarcinomas.^15,16 NKX3.1 stains nuclei in both normal and prostate cancer.¹⁶ The addition of IHC staining for NKX3.1, along with other prostaterestricted markers, may prove to be a valuable adjunct to definitively determine prostatic origin in poorly differentiated metastatic carcinomas.^17,18

Specifications

1. Bowen C, Gelmann EP. NKX3.1 activates cellular response to DNA damage. Cancer Res. 2010 Apr 15; 70(8):3089-97.
2. Gurel B, et al. NKX3.1 as a marker of prostatic origin in metastatic tumors. Am J Surg Pathol. 2010 Aug; 34(8):1097-105.
3. Chuang AY, et al. Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma. Am J Surg Pathol. 2007 Aug; 31(8):1246-55.
4. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
5. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991; 7(9). Order code M29-P.