PRAME [EPR20330]

Product Description

PRAME is located on chromosome 22q11.22 and encodes a 509 amino acid protein. PRAME is an autosomal cancer-testis antigen (CTA) gene which has been shown to be expressed in melanoma, various nonmelanocytic malignant neoplasms, including non-small cell lung cancer, breast carcinoma, renal cell carcinoma, ovarian carcinoma, leukemia, synovial sarcoma, and myxoid liposarcoma. Normal healthy tissues are not known to express PRAME except for testis, ovary, adrenals, and endometrium.^15,16

Specifications

1. Zhang W, Barter CJ, Eng KH, et al. PRAME expression and promoter hypermethylation in epithelial ovarian cancer. Oncotarget 2016 Jul; 7(29): 45352-45369. 2. Lezcano C, Jungbluth AA, Nehal KS, et al. PRAME expression in melanocytic tumors. Am J Surg Pathol. 2018 Nov; 42(11): 1456–1465. 3. Salmaninejad A, Zamani, MR, Pourvahedi M,et al. Cancer/testis antigens: expression, regulation, tumor invasion and use in immunotherapy cancers. Immunol Invest 2016 Oct; 45(7): 619-640. 4. Al-Khadairi G, Decock J. Cancer testis antigens and immunotherapy: where do we stand in the targeting of PRAME? Cancers 2019 Jul; 11(7): 984. 5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.” 6. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.