This Cytokeratin [AE1] LMW Antibody recognizes the acidic (Type 1) subfamilies of cytokeratins and shows a broad species reactivity. The acidic cytokeratins have molecular weights of 56.5, 50, 50, 48 and 40 kDa (CK10, CK14, CK15, CK16 and CK19, respectively). [AE1] has been shown to be useful for marking tumors for squamous and adenocarcinoma of the lung, liver carcinoma, breast cancer and esophageal cancer. Cytokeratin [AE1] LMW may be useful to aid in the identification of nodal metastases missed by routine H&E examination.
1. Waterman TA, et al. Ann Thorac Surg. 2004 Oct; 78(4):1161-9; discussion 1161-9.
2. Vollmer RT, et al. Clin Cancer Res. 2003 Nov 15; 9(15):5630-5.
3. Viana EF, et al. J Surg Oncol. 2009 Dec 1; 100(7):534-7.