MSH6

Product Description

MSH6 functions, along with MSH2, MLH1, and PMS2, as part of the DNA mismatch repair (MMR) pathway, are utilized by normal proliferating cells to repair mutations that may occur during DNA replication.16 MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop.^1,2 Antibodies to MSH6 may be a useful aid for classification of tumors of the gastrointestinal tract, including colorectal cancers.²

Specifications

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Sordet C, Goetz J, Sibilia J. Contribution of autoantibodies to the diagnosis and nosology of inflammatory muscle disease. Joint Bone Spine. 2006 Dec;73(6):646-54.
2. Peltomäki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 2003,21:1174-9.5.