MLH-1

Product Description

The G168-15 antibody recognizes human and mouse MLH-1 (80-85 kDa).¹ MLH1 functions, along with MSH2, PMS2, and MSH6, as part of the DNA mismatch repair (MMR) pathway, are utilized by normal proliferating cells to repair mutations that may occur during DNA replication. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMS2. Antibodies to MLH1 may be a useful aid for classification of tumors of the gastrointestinal tract, including colorectal cancers.^1-3

Specifications

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Vilkin, A, et al. Immunohistochemistry staining for mismatch repair proteins: the endoscopic biopsy material provides useful and coherent results. Hum Pathol 2015;46:1705–11.
2. Sordet C, Goetz J, Sibilia J. Contribution of autoantibodies to the diagnosis and nosology of inflammatory muscle disease. Joint Bone Spine. 2006 Dec;73(6):646-54.
3. Peltomäki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 2003,21:1174-9