All three antibodies in this combination recognize distinct epitopes in the hydrophilic carboxyl region of the latent membrane protein (LMP) protein encoded by the Epstein Barr Virus antibody (EBV). EBV has been implicated with Hodgkin’s disease, and may be involved in the pathogenesis of Hodgkin’s occurring in children. Other studies have shown a low incidence of EBV in B-cell type lymphomas unless patients were immunologically impaired, such as post-organ transplantation or autoimmune type diseases. Studies have shown that this antibody does stain EBV + Burkitt’s lymphomas but has shown some cross reactivity with smooth muscle and blood vessels.
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