Desmoglein 3 (DSG3) + Napsin A are very sensitive and specific markers, and may be useful for discriminating between lung SqCC and lung adenocarcinoma. DSG3 is a membrane stain that marks lung SqCC while Napsin A is a cytoplasmic stain that marks lung adenocarcinomas. In the vast majority of lung cancers tested, only a single antibody stain was observed. Coexpression of both antibodies may be observed in adenosquamous cell carcinomas and Napsin A staining is observed in some cases of residual normal lung. In grades 1-2, Desmoglein 3 + Napsin A provide staining sensitivity in the mid 90% range.
Available individually or as part of the PulmoPanel™ Multiplex Kit. Cat No: PPM 436 AAK