Desmoglein 3 + CK5


Desmoglin 3 (DSG3) is often highly expressed in various squamous cell carcinomas (SqCC). In studies of lung SqCC, DSG3 has demonstrated a sensitivity of 85-99% and an ability to discriminate lung adenocarcinoma with a specificity of 98-100%. Numerous studies have shown CK5/6 to be a sensitive marker for lung SqCC. Two sudies using a cocktail of DSG3 + CK5 antibody reported sensitivities of 93% and 100% for lung SqCC, with a specificity of 100% vs. lung adenocarcinoma. Studies have also shown that a DSG3 and CK5 cocktail provides superior sensitivity and specificity, compared to alternative markers for lung SqCC.

Intended Use


Species Reactivity



Mouse Monoclonal


BC11 + XM26, Biocare Clone


IgG1 + IgG1/kappa


Desmoglein 3 and CK5


Desmoglein 3: membrane; CK5: cytoplasmic

Positive Control

Lung squamous cell carcinoma

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

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4. Agackiran Y, et al. Appl Immunohistochem Mol Morphol. 2012 Jul; 20(4):350-5.
5. Mukhopadhyay S, et al. Am J Surg Pathol. 2011 Jan; 35(1):15-25.
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8. Brown AF, et al. Arch Pathol Lab Med. 2013 Jan 4. [Epub ahead of print]


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