Cytokeratin HMW [34βE12] antibody recognizes Cytokeratins 1, 5, 10 and 14. This antibody is expressed in squamous and adenosquamous carcinomas and is negative in adenocarcinomas. In normal epithelia, [34βE12] stains stratified epithelia, myoepithelial cells and basal cells in the prostate gland and bronchi. It is also expressed in ductal and squamous epithelium over a wide range of organ tissues. Studies have shown that [34βE12] is useful as a differential marker for squamous carcinomas and adenocarcinomas as well as for benign and malignant tumors of the prostate gland.