Product Description
The Cytokeratin 5 (CK5) (R) [EP42] antibody is a rabbit monoclonal antibody raised for the detection of cytokeratin 5, a type II intermediate filament protein. CK5 is expressed in the active basal layers of most stratified squamous epithelia.15 CK5 has been identified as a specific immunohistochemical marker for lung squamous cell carcinoma (SqCC), with minimal expression in lung adenocarcinoma.16,17 In a published study comparing rabbit monoclonal CK5 to mouse monoclonal CK5/6, CK5 demonstrated 84% sensitivity and 100% specificity for lung SqCC, whereas CK5/6 showed 80% sensitivity and 97% specificity.16,17 These findings support CK5 as a potentially more specific marker for lung SqCC, as CK6 mRNA has been detected in lung adenocarcinomas. The CK5 antibody has been optimized for use in the detection of lung squamous cell carcinoma. Other tumor types have not been evaluated. CK5 is also distributed in various non-keratinizing stratified squamous epithelia, including the mucosa of the tongue, basal epithelial layers, hair follicles, and trachea. Expression is also observed in basal cells of the prostate gland and myoepithelial cells of mammary glands.18 Additionally, CK5 is expressed in most epithelial and biphasic mesotheliomas.18
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