Cytokeratin 20 antibody is an intermediate filament protein that is expressed in adenocarcinomas of the colon, stomach, pancreas, bile system and mucinous ovarian tumors, transitional cell carcinomas of the urinary tract, and Merkel cell carcinomas. CK20 is essentially non-reactive in squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, as well as non-mucinous tumors of the ovary and small cell carcinomas. Cytokeratin 20 is often used in conjunction with CK7 and other antibodies in distinguishing colon carcinomas (CK20+) from ovarian, pulmonary, and breast carcinomas.
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