CDX2 (RM)
Price range: $270.00 through $774.00
Description
Product Description
The Biocare CDX2 antibody detects CDX2, a homeobox gene–encoded, intestine-specific transcription factor.15 CDX2 is useful in establishing the gastrointestinal origin of metastatic adenocarcinomas and carcinoids and can aid in distinguishing metastatic colorectal adenocarcinoma from tumors of unknown origin.15-21 Studies have shown that CDX2 to be more specific and sensitive than villin or CK20.15,19,20 CDX2 expression has also been observed in mucinous ovarian cancer, bladder adenocarcinoma, cholangiocarcinoma, and malignant germ cell tumors of the testes.15,16,20-22 Only rare cases of carcinomas of the genitourinary and gynecologic tracts, or cancers of the breast, lung, and head and neck, show elevated CDX2 expression.15 Overall specificity can be further improved when CDX2 is used in a panel with CK7, TTF-1, and CDH17.17,18,20,24
Specifications
Specifications
| Intended Use | |
|---|---|
| Format | |
| Volume | |
| Source | |
| Clone | |
| Isotype | |
| Antigen | A synthetic peptide corresponding to residues near the C-term of human CDX2 protein |
| Localization | |
| Species Reactivity |
Datasheets & SDS
| Download CE Marked IVD Datasheet |
| Download IVD Datasheet Without CE Mark |
| Download RUO Datasheet |
| Download SDS Sheet |
Browse more documents for this product (IFUs, datasheets, translations, SDS, and more).
References
1. Werling RW, et al. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol. 2003 Mar;27(3):303-10.
2. Moskaluk CA, et al. Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays. Mod Pathol. 2003 Sep;16(9):913-9.
3. Kim JH, et al. Utility of thyroid transcription factor-1 and CDX-2 in determining the primary site of metastatic adenocarcinomas in serous effusions. Acta Cytol. 2010 May-Jun;54(3):277-82.
4. Saad RS, et al. CDX2, cytokeratins 7 and 20 immunoreactivity in rectal adenocarcinoma. Appl Immunohistochem Mol Morphol. 2009 May;17(3):196-201.
5. Qi W, et al. Characterization and applications of a newly developed rabbit monoclonal antibody to cytokeratin 7 (CK7) for immunohistochemistry. Appl Immunohistochem Mol Morphol. 2009 May;17(3):233-8.
6. Bayrak R, Haltas H, Yenidunya S. The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: cytokeratin 7-/20+ phenotype is more specific than CDX2 antibody. Diagn Pathol. 2012 Jan 23;7:9.
7. Lee MJ, et al. CDX-2 expression in malignant germ cell tumors of the testes, intratubular germ cell neoplasia, and normal seminiferous tubules. Tumour Biol. 2012 Dec;33(6):2185-8.
8. Vang R, et al. Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Mod Pathol. 2006 Nov;19(11):1421-8.
9. Borrisholt M, Nielsen S, Vyberg M. Demonstration of CDX2 is highly antibody dependent. Appl Immunohistochem Mol Morphol. 2013 Jan;21(1):64-72.
10. Panarelli NC, et al. Tissue-specific cadherin CDH17 is a useful marker of gastrointestinal adenocarcinomas with higher sensitivity than CDX2. Am J Clin Pathol. 2012 Aug; 138(2):211-22.
11. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
12. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.
