CD47 [EPR21794]

Product Description

CD47 has been shown to have a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins.¹⁵ In the brain, it appears to play an important role in memory formation and synaptic plasticity in the hippocampus.¹⁶ CD47 is a receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.¹⁷ Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cellmediated proliferation and costimulates T-cell activation.¹⁵ CD47 may play a role in membrane transport and/or integrin dependent signal transduction. CD47 has been described as broadly expressed in many human tissues, with abundant expression in epithelial cells, the brain, and in ovarian cancer.¹⁸

Specifications

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