CD44

Product Description

CD44 is a transmembranous glycoprotein (80 kDa) responsible for cell adhesion that is expressed in a wide range of normal tissues, such as tonsil, breast, prostate, skin, bladder and cervical squamous epithelium.¹⁵ Studies have shown that CD44, also known as HCAM, plays an important role in the cascade of metastasis and progression of human malignant tumors.¹⁶ In breast cancer studies, evaluation of CD44 expression has been useful in the differentiation of benign and malignant papillary lesions.¹⁶ CD44, as part of a panel that includes CK20, p53, and AMACR, has been shown to be useful in differentiating urothelial carcinoma in situ from normal urothelium or reactive urothelial atypia.^17,18 The CD44 predilute (PM380) has been titered specifically for use in bladder cancer.

Specifications

1. Balic M, et al. Clin Cancer Res. 2006 Oct; 12(19):5615-21.
2. Diaz LK, et al. Clin Cancer Res. 2005 May; 11(9):3309-14.
3. Tse GM, et al. J Clin Path. 2005 Nov; 58(11):1185-8.