CD44 Antibody is a transmembranous glycoprotein (80 kDa) present on T lymphocytes, granulocytes, red blood cells, brain, and epithelial cells. Studies have shown that the standard isoform, CD44s, is expressed in a wide range of normal tissues such as tonsil, skin, bladder, and cervical squamous epithelium. In breast cancer studies, CD44 expression, assessed by IHC, demonstrated a favorable prognostic factor in patients with node-negative invasive breast carcinoma. Further studies have shown a subpopulation of CD44+/CD24- cells in breast cancer have stem/progenitor cell properties.
1. Balic M, et al. Clin Cancer Res. 2006 Oct; 12(19):5615-21.
2. Diaz LK, et al. Clin Cancer Res. 2005 May; 11(9):3309-14.
3. Tse GM, et al. J Clin Path. 2005 Nov; 58(11):1185-8.