CD33
$295.00 – $1,626.00
Description
Product Description
The Biocare CD33 antibody detects CD33 (Siglec-3), a 67 kDa glycosylated transmembrane receptor expressed on myeloid-specific cells.15, 16 Historically, CD33 was primarily used for flow cytometry; more recently, a paraffin embedded tissue–compatible CD33 antibody has been developed. CD33 is useful for phenotyping acute myelogenous leukemias, with immunohistochemical (IHC) analysis providing results equivalent to flow cytometry.15, 16 It is also valuable in the evaluation of myeloid sarcomas.15, 17 In normal bone marrow trephine biopsies, clone PWS44 stains myeloid and myelomonocytic lineages, as well as mature macrophages, while erythroid and megakaryocyte series are negative for CD33.15
Specifications
Specifications
| Intended Use | |
|---|---|
| Format | |
| Volume | |
| Source | |
| Clone | |
| Isotype | |
| Antigen | Prokaryotic recombinant protein corresponding to a region of the C2 domain on human CD33 |
| Localization | |
| Positive Control |
Datasheets & SDS
| Download CE Marked IVD Datasheet |
| Download IVD Datasheet Without CE Mark |
| Download RUO Data Sheet |
| SDS Sheet |
Browse more documents for this product (IFUs, datasheets, translations, SDS, and more).
References
1. Hoyer JD, et al. CD33 detection by immunohistochemistry in paraffin-embedded tissues: a new antibody shows excellent specificity and sensitivity for cells of myelomonocytic lineage. Am J Clin Pathol. 2008 Feb; 129(2):316-23.
2. Rollins-Raval MA, Roth CG. The value of immunohistochemistry for CD14, CD123, CD33, myeloperoxidase and CD68R in the diagnosis of acute and chronic myelomonocytic leukaemias. Histopathology. 2012 May; 60(6):933-42.
3. Amador-Ortiz C, et al. Use of classic and novel immunohistochemical markers in the diagnosis of cutaneous myeloid sarcoma. J Cutan Pathol. 2011 Dec; 38(12):945-53.
4. Brotelle T, et al. Gemtuzumab ozogamicin for treatment of acute myeloid leukemia. Bull Cancer. 2014 Feb; 101(2):211-8.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.
