α-Methylacyl coenzyme A racemase (AMACR), also known as P504S, is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β oxidation of branched chain fatty acids (1).
AMACR was initially identified from a cDNA library as a gene that is overexpressed in human prostate cancer; with little or no expression in normal or benign prostate glands (2-3). In immunohistochemistry, AMACR has been shown to be a marker of prostatic adenocarcinoma (2-5).
Additionally, prostate glands involved in prostatic intraepithelial neoplasia (PIN), have been found
to express AMACR; whereas AMACR was nearly undetectable in benign glands (5-6).